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　　32岁的劳伦·柯伦（克里斯蒂娜·里奇）和丈夫罗素（布莱登·佛雷切）搬进了设备先进齐全的新公寓。刚刚因为失去孩子而遭受了心理创伤患躁郁症的劳伦对公寓的安保监控系统很满意，但随后发现公寓里有些不对劲，她怀疑酒店的拥有者暗中非法操控住在其中的用户，但她的丈夫认为这些都是她的想象。劳伦独自开始调查建造公寓的公司，并雇佣了一个帮手-阴谋论者弗侬·沙斯菲尔德（约翰·库萨克）。弗侬认为这间公寓是个试验场所，里面的住户是个巨大洗脑阴谋的小白鼠。随着调查深入，劳伦也遇到了生命威胁……

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性格内向的律师梅尔·戴尔得知她爱冒险的妹妹突然去世后感到悲痛欲绝。但当她前往收集姐姐的尸体时，她很快就怀疑有人谋杀。她可能是下一个。

　　The boisterous, arrogant professor Challenger, a reputed biologist and anthropologist, dares the London Zoological Society to mount an expedition to verify his spectacular claim, without physical proof, that his previous expedition to the Amazonian basin found live dinosaurs. Apart from him and his 'socialite' counterpart, professor Summerlee, it consists of experienced discoverer Lord Roxbury, the young reporter Ed Malone -who got publicly struck down with Challenger's umbrella at his arrival- and Jennifer Holmes, Malone's news agency's boss's daughter, essentially as conditions for putting up the money. In Brazil they are joined by Jennifer's brother David and local 'guide' Manuel Gomez. They soon discover the dinosaurs are real and dangerous, like giant spiders, but loose their helicopter and thus are desperate for a way down from the isolated plateau. They learn Roxbury knew about the fate of Burton White, an explorer whose diary they find, thus presume to be dead, in search of diamonds, and confirmation of the local tribe being the lethal guardians of the plateau's secrets, but also get surprising help...